As someone on the spectrum, I don’t necessarily know if this is something I would want. My ASD is a big part of my personality; if these social “difficulties” (which really just mean I click with a different type of person) were “solved” I don’t know I would be the same person.
Maybe this can offer some hope for others with more profound issues, but if you’ve found a way to function in society I’m not sure this will be very attractive outside a “let me try and see what it feels like” scenario.
HDAC inhibitors have been discussed before on /r/nootropics and Longecity. I was part of a group buy for Vorinostat, which is a medication with a similar mechanism of action. I only took it once and had a positive experience where I felt very "child-like", in the way that the world seemed vivid and exciting. I haven't taken it since due to concerns about interactions with some of my other medications.
The primary goal of many of the people in the group buy were fear extinction and memory enhancement. I haven't seen much discussion on it since the initial excitement.
Here are the relevant threads:
Another HDAC inhibitor that works against autism and is easy to obtain by eating broccoli sprouts is sulforaphane: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672987/
Mostly parents will be into this. No one would do this to themselves as they will have similar feelings as most (they don't want to give up who they are).
Wether being on the spectrum has been good or bad for you; it is you.
However parents are really great here; they really don't give a crap about their kids feelings they just want the _best_ for him.
> What I mean is they don't want to be embarrassed by their child.
I know this for a fact ... I used to think my mother was trying to get me all the help in the world but no she wanted a normal child at all costs.
An obvious question is whether this could also be used as a nootropic by non-autistic individuals, and what effect (if any) it would have.
The above mentioned study links raising HDAC2 to reverse effects of Alzheimer's disease.
I doubt that the autism study with mice really 'cured' autism. I think the cancer drug reduced cognitive abilities, so mice seemed to react 'normal'.
I learned a lot about autism, cancer, and many causes (e.g. our food system, glyphosphate (weed killer), our sterile environment) from the endocrinologist and cancer researcher Dr Zach Bush on this podcast. Very fascinating stuff. http://www.richroll.com/podcast/zach-bush-353/
Though I often question if society should treat social deficits of autism even if such a treatment is effective without side-effects.
Another solution would be for society to be generally more neuro-inclusive. I can't help but wonder if there are synergistic benefits from being able to have different ways of experiencing the world.
(I don't have ASD; my step-daughter is on the spectrum).
My child is on the spectrum, but I love him as he is and he is happy as he is. He is funny and quirky, my mother says I was similar as a child.
Plus, he just won his school prize for Year 9 EMITS (STEM) so not sure why I would want to mess with what might make him like that.
This drug is naturally occurring and derived from a bacteria that is found in soil. Curious about a link between kids not playing in the dirt enough and autism.
Second, this drug is used to treat lymphoma. Surely their have been kids with autism who also had lymphoma who were exposed to this drug. Would be useful to look and see if there are cases of autism being cured along with lymphoma treatment (thanks to my mom, @DrJanetRose for that insight).
I would like to see a chart of the autism spectrum.
Cause from where I am standing we are all on the spectrum but where are people and when is even worth talking about the spectrum.